Modulation of carotid strain by statin therapy in atherosclerosis patients.

Background: The beneficial effect of statin therapy on the progress of atherosclerotic disease has been demonstrated by numerous studies. Vascular strain imaging is an arising method to evaluate arterial stiffness. Our study examined whether an influence of statin therapy on the vessel wall could be detected by vascular strain imaging. Patients and methods: 88 patients with recently detected atherosclerosis underwent an angiological examination including ankle-brachial index (ABI), pulse wave index (PWI), central puls ewave velocity and duplex ultrasound. Captures for vascular strain analysis were taken in B-mode during ultrasound examination of the common carotid artery and evaluated using a workstation equipped with a speckle tracking based software. A statin therapy was recommended and after six months a follow-up examination took place. Meanwhile, the non-adherence of a group of patients (N = 18) lead to a possibility to observe statin effects on the vascular strain. Results: In the statin non-adherent group the ABI decreased significantly to a still non-pathological level (1.2 +/- 0.2 vs. 1.0 +/- 0.2; p = 0.016) whereas it stagnated in the adherent group (1.0 +/- 0.2 vs. 1.0 +/- 0.2; p = 0.383). The PWI did not differ in the non-adherent group (180.5 +/- 71.9 vs. 164.4 +/- 75.8; p = 0.436) but under statin therapy it decreased significantly (261.8 +/- 238.6 vs. 196.4 +/- 137.4; p = 0.016). In comparison to the adherent group (4.2 +/- 2.0 vs. 4.0 +/- 1.8; p = 0.548) under statin therapy the radial strain decreased significantly in the non-adherent group (4.7 +/- 2.0 vs. 3.3 +/- 1.1; p = 0.014). Conclusions: Our findings reveal a beneficial influence of statin therapy on the arterial wall detected by vascular strain analysis.