Complementary Pharmacological And Toxicological Characterization Data On The Pharmacological Profile Of N-(2,6-Dichloropheny1)-2-(4-Methyl-1-Piperidinyl) Acetamide

This text presents complementary data corresponding to pharmacological and toxicological characterization of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA) compound. These data support our research article entitled "Pharmacological profile of N-(2,6-dichlorophenyl) 2 (4 methyl-l-piperidinyl)acetamide, a novel analog of lidocaine" Deciga-Campos M., Navarrete-Vazquez G., Lopez Munoz FJ., Librowski T., Sanchez-Recillas A., Yanez-Perez V., Ortiz-Andrade R. (2016) [1]. Toxicity was predicted through the ACD/ToxSuite software and evaluated in vivo using brine shrimp larvae (Artemia sauna L) and mice. Also, we used the micronucleus assay to determine genotoxicity. We used the platform admetSAR to predict absorption properties of LIA and lidocaine. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.