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Novel benzothiazine-piperazine derivatives by peptide-coupling as potential anti-proliferative agents.

Ramineni Venkatesh,Suresh Kasaboina, Deepthi Bidayat, U Nikhil Kumar,Nishant Jain, Saritha Jostna Tangeda,Rajashaker Bantu,Sridhara Janardhan,Lingaiah Nagarapu

Bioorganic & Medicinal Chemistry Letters（2017）

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Abstract
Novel benzothiazine-piperazine derivatives 8a–i and 10a–g has been synthesized by peptide-coupling and screened for their anti-proliferative activity against human cancer cell lines of HeLa, MIAPACA, MDA-MB-231 and IMR32.
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Key words
Peptide-coupling,Anti-proliferative activity,Molecular docking,Benzothiazine-piperazine,HDAC8,EHMT2
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