Isotretinoin increased carotid intima-media thickness in acne patients.

Background: Isotretinoin (Iso) in acne treatment may cause dyslipidemia and increase in liver enzymes. Moreover, its effect on lipid and glucose metabolism may induce atherosclerotic complications. The aim of this study was to evaluate carotid intima-media thickness (CIMT), osteopontin (OPN), lipid, high sensitive C-reaktive protein (hs-CRP) levels, and insulin resistance (HOMA-IR) in acne patients before and after Iso treatment. Materials: Twenty-one acne patients were treated with Iso (0.5-0.8 mg/kg) for four months. Blood tests for lipid profile, fasting glucose, liver enzymes, OPN, HOMA-IR, hs-CRP and CIMT measurements were performed before and after Iso treatment. Serum levels of OPN and, hs-CRP were measured by ELISA and particle-enhanced turbidimetric immunoassay respectively. Results: Iso treatment significantly increased lipid levels, CIMT (0.60-0.74 mm; p<0.001); whereas it non-significantly increased HOMA-IR (0.91-1.87; p = 0.70), OPN (4.32-5.44 ng/ml; p = 0.27), and hs-CRP (0.08-0.09 mg/dl; p = 0.88) levels. There was no correlation between OPN and CIMT (p = 0.77). Conclusion: Isotretinoin treatment for four months significantly increased CIMT in acne patients.