HRI, a stress response eIF2α kinase, exhibits structural and functional stability at high temperature and alkaline conditions

Varsha Bhavnani,Kaviraj Swarnendu,Laxman Savergave,Arjun Singh Raghuwanshi,Ankit Kumar, Avinash Kumar,Jayanta Pal

International Journal of Biological Macromolecules（2017）

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摘要

•Cloning, expression and purification of catalytic kinase domain of HRI has been carried out.•Structure-function relationship of HRI upon temperature mediated stress is elucidated.•HRI represents an inherent stable structure and it functions at an alkaline pH.

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关键词

Heme Regulated Inhibitor (HRI),Thermal unfolding,Alkaline stability,CD,DSC

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