Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor.
Journal of Allergy and Clinical Immunology(2017)
摘要
The association of mitochondrial MITF with PDH emerges as an important regulator of mast cell function. Our findings indicate that PDH could arise as a new target for the manipulation of allergic diseases.
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关键词
Allergy,mast cells,degranulation,cytokines,pyruvate dehydrogenase,microphthalmia transcription factor,asthma,mitochondria
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