Using Tiletamine-Zolazepam-Xylazine Anesthesia Compared to CO 2 -inhalation for Terminal Clinical Chemistry, Hematology, and Coagulation Analysis in Mice.

The studied method of mouse anesthesia, followed by terminal blood sampling and analysis of clinical pathology parameters, suggests that TZX is a good alternative to CO inhalation in toxicological and other nonclinical studies. The differences in hemostasis, hematology, and clinical chemistry parameters between these groups are supposedly associated with alterations in physiological and metabolic status of mice under conditions of increasing hypoxia, respiratory standstill, and circulatory arrest after CO inhalation.