Involvement of NF-κB in regulation of Actinobacillus pleuropneumoniae exotoxin ApxI-induced proinflammatory cytokine production in porcine alveolar macrophages.

Chiung-Wen Hsu,Siou-Cen Li,Nai-Yun Chang,Zeng-Weng Chen,Jiunn-Wang Liao,Ter-Hsin Chen,Jyh-Perng Wang,Jiunn-Horng Lin,Shih-Ling Hsuan

Veterinary Microbiology（2016）

引用 11|浏览6

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摘要

•ApxI activates the classical NF-κB pathway in porcine alveolar macrophages (PAMs).•NF-κB mediates the production of IL-1β, IL-8, and TNF-α in PAMs by ApxI.•JNK, but not p38, affects NF-κB DNA binding activity.•JNK mediates the phosphorylation of the NF-κB p65 subunit at Ser536.

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关键词

Actinobacillus pleuropneumoniae,ApxI,Proinflammatory cytokines,NF-κB,Mitogen-activated protein kinases

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