Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity.

Rick Morrison,Zhaohua Zheng,Ian G Jennings,Philip E Thompson,Jasim M A Al-Rawi

Bioorganic & Medicinal Chemistry Letters（2016）

引用 12|浏览12

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摘要

•Suzuki coupling novel linear and angular fused-aryl-morpholino-naphth-oxazines.•Linear 6.7-fused 13a and 13b selective PI3Kδ isoform inhibitors (IC50=7.7 and 5.61μM).•Antiplatelet activity for the angular 7,8-fused 22a, b, k and l with IC50=3.0,14.0, 2.0 and 5.0μM.

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