Deoxycholic acid derivatives as inhibitors of P-glycoprotein-mediated multidrug efflux.

•Deoxycholic acid derivatives were identified as P-glycoprotein modulators.•All derivatives were evaluated through daunorubicin accumulation in K562/R7 cells.•All derivatives were evaluated through potentiation of doxorubicin in K562/R7 cells.•Intrinsic toxicity of all derivatives was evaluated on K562 cells.•Some deoxycholic acid derivatives are more active and less toxic than cyclosporine A.