Magnetization of 3-dimentional homochiral metal-organic frameworks for efficient and highly selective capture of phosphopeptides.

•A 3D magnetic homochiral metal-organic frameworks was prepared using a facile method.•Based on it, a rapid and efficient phosphopeptide enrichment method was developed using magnetic solid phase extraction within 10min.•Efficient and highly selective capture of phosphopeptides from tryptic digests and human serum was obtained.•Fe3O4@ZnBLD particles showed satisfactory reproducibility of the synthesis and could be reused for at least seven times.