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TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways.

Run-Wei Yang,Ying-Yue Zeng,Wen-Ting Wei,Yan-Mei Cui,Hui-Ying Sun,Yue-Long Cai,Xin-Xin Nian,Yun-Teng Hu,Yu-Ping Quan,Sheng-Lu Jiang,Meng Wang,Ya-Li Zhao,Jun-Feng Qiu,Ming-Xuan Li,Jia-Huan Zhang,Mei-Rong He,Li Liang,Yan-Qing Ding,Wen-Ting Liao

Journal of experimental & clinical cancer research : CR（2016）

Cited 16|Views19
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Abstract
This study indicated that TLE3 repressed CRC proliferation partly through inhibition of MAPK and AKT signaling pathways, suggesting the possibility of TLE3 as a biomarker for CRC prognosis.
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Key words
Colorectal cancer,Prognosis,Proliferation,TLE3,p21Cip1/WAF1,p27Kip1
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