The effect of the NMDA receptor-dependent signaling pathway on cell morphology and melanosome transfer in melanocytes.

•NMDA receptor-dependent signaling regulates cell morphology in melanocyte.•NMDA receptor-dependent signaling regulates melanosome transfer in melanocytes.•NMDA receptor antagonist MK-801 blocks calcium influx in melanocyte.•NMDA receptor antagonist MK-801 leads to β-tubulin distribution in melanocyte.•The results of this study are crucial for designing treatments for the pigmentary dermatosis.