RETRACTED: The effects of tanshinone IIA on hypoxia/reoxygenation-induced myocardial microvascular endothelial cell apoptosis in rats via the JAK2/STAT3 signaling pathway

Biomedicine & Pharmacotherapy(2016)

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摘要
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier. Concern was raised about the reliability of the flow cytometry data shown in Figures 5, 7, and 8, which appears to contain similar repeating features, as detailed here: https://pubpeer.com/publications/B7A8CA625357F2A4DCEAC0E5AA276A; and here https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Independent analysis confirmed these findings and also identified additional suspected image duplications within the β-actin bands in Figure 9A, and between the Bcl-2 and Bax-2 Western blots in Figure 10A. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.
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关键词
Tanshinone IIA,JAK2/STAT3,Hypoxia/reoxygenation,Myocardial microvascular endothelial cell,Apoptosis,Cell cycle,Tri-gas incubator,Primary culture
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