Evaluation of a subset of tumor suppressor gene for copy number and epigenitic changes in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma carcinogenesis.

Fernanda Viviane Mariano,Erika Said Egal,Dimitrius Pramio,Felipe Fidalgo, Érica Sara,Ana Flávia Costa,Rogério de Oliveira Gondak,Ricardo Della Coletta,Oslei Paes de Almeida,Luiz Paulo Kowalski,Ana Cristina Victorino Krepischi,Albina Altemani

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology（2016）

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摘要

CASP8, MLH1, and RARB tumor suppressor genes were altered by copy number losses during PA progression to CXPA. Lastly, RASSF1 inactivation by methylation was also detected in both tumors.

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关键词

tumor suppressor gene,carcinoma,copy number,ex-pleomorphic

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