Sequence adaptations during growth of rescued classical swine fever viruses in cell culture and within infected pigs.

Johanne Hadsbjerg,Martin B Friis,Ulrik Fahnøe,Jens Nielsen,Graham J Belsham,Thomas Bruun Rasmussen

Veterinary Microbiology（2016）

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摘要

•CSFVs were rescued from full-length cloned cDNAs and passaged in cell culture.•Specific adaptations occurred within the virus coding sequence in cell culture.•The same virus adaptations in two proteins occurred during infection of swine.•Modifications to the CSFV IRES attenuated the virus in swine.•Swine infected with these attenuated viruses seroconverted against CSFV.

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Pestivirus,Next generation sequencing (NGS),Attenuation,IRES,Reverse genetics

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