Antibodies against peptides of NMDA-type GluR in cerebrospinal fluid of patients with epileptic spasms.

Tatsuo Mori,Yukitoshi Takahashi,Nami Araya,Taikan Oboshi,Hirokazu Watanabe,Kazuki Tsukamoto,Tokito Yamaguchi,Shinsaku Yoshitomi,Hirosato Nasu,Hiroko Ikeda,Hideyuki Otani,Katsumi Imai,Hideo Shigematsu,Yushi Inoue

European Journal of Paediatric Neurology（2016）

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摘要

•The role of antibodies to NMDA-type GluR in CSF was investigated in ES patients.•Significant difference of the antibodies between ES and disease controls was shown.•Predictive value of antibodies for outcome was not confirmed.•GluN2B antibodies were higher especially in ES patients with unknown cause.•We suggested possible contribution of GluN2B antibodies to motor and cognitive outcomes.

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关键词

West syndrome,Infantile spasms,Autoantibodies,Cognitive outcome,Motor outcome

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