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Infection of human uterine fibroblasts by Zika virus in vitro: implications for viral transmission in women.

International Journal of Infectious Diseases(2016)

Cited 24|Views7
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Abstract
•Human uterine fibroblasts are susceptible to Zika virus infection.•Both African and Puerto Rican Zika strains can infect human uterine fibroblasts.•A quantitative reverse transcription PCR with primers targeting the envelop regions of the virus was utilized.•Uterine fibroblasts continually produced virus, while maintaining cellular viability over 5 days.•Uterine fibroblasts may be linked with heterosexual transmission of Zika virus in women.
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Key words
Zika virus,Uterine fibroblasts,Heterosexual transmission,Viral detection,Women's health
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