Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.
Bioorganic & Medicinal Chemistry Letters（2016）
摘要
Design and optimization of a novel series of imidazo[1,2-b]pyridazine PDE10a inhibitors are described. Compound 31 displays excellent pharmacokinetic properties and was also evaluated as an insulin secretagogue in vitro and in vivo.
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关键词
PDE10a inhibitor,Insulin secretagogues,Type 2 diabetes,GPCR,GSIS,Brain penetration
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