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Synthesis, anticancer activity and photostability of novel 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones.

Anelia Ts Mavrova,Stefan Dimov,Denitsa Yancheva,Miroslav Rangelov,Diana Wesselinova,Jordan A Tsenov

European Journal of Medicinal Chemistry（2016）

Cited 35|Views3
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Abstract
Some derivatives of 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized using ethyl 2-aminothiophene-3-carboxylates as precursors in order to estimate their cytotoxicity, respectively proliferative activity.
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Key words
Thieno[2,3-d]pyrimidin-4(3H)-ones,DFT,Cytotoxicity,Photo stability,Anticancer activity,B-Raf
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