Synergy and antagonism between iron chelators and antifungal drugs in Cryptococcus.

International Journal of Antimicrobial Agents(2016)

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摘要
•Iron chelators were tested for synergy with antifungal drugs against Cryptococcus.•Interactions between chelators and antifungals were uncommon.•Lactoferrin was synergistic with amphotericin B for all strains of Cryptococcus.•Azole drugs were antagonised by some chelators in Cryptococcus neoformans var. grubii.
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关键词
Cryptococcus,Lactoferrin,Amphotericin B,Antifungal drug synergy,Metal ion homeostasis
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