A model of cooperative effect of AMPA and NMDA receptors in glutamatergic synapses
Cognitive neurodynamics(2016)
Abstract
Glutamatergic synapses play a pivotal role in brain excitation. The synaptic response is mediated by the activity of two receptor types (AMPA and NMDA). In the present paper we propose a model of glutamatergic synaptic activity where the fast current generated by the AMPA conductance produces a local depolarization which activates the voltage- and [Mg 2+ ]-dependent NMDA conductance. This cooperative effect is dependent on the biophysical properties of the synaptic spine which can be considered a high input resistance specialized compartment. Herein we present results of simulations where different values of the spine resistance and of the Mg 2+ concentrations determine different levels of cooperativeness between AMPA and NMDA receptors in shaping the post-synaptic response.
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Key words
AMPA,Glutamatergic synapse,Membrane resistance,NMDA,Synaptic model,Synaptic plasticity
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