Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo

•Resazurin is effective against Neisseria gonorrhoeae in vitro but not in vivo.•Serum albumin likely inactivates resazurin in vivo.•Resorufin pentyl ether (RPE) exhibits activity in the presence of serum albumin.•RPE reduces vaginal colonisation by N. gonorrhoeae over time.•Resazurin-based therapies could have potential for the treatment of gonorrhoea.