Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.

Stephanie J Nakano,Juliana Sucharov, Robert van Dusen,Mackenzie Cecil,Karin Nunley,Sean Wickers,Anis Karimpur-Fard,Brian L Stauffer,Shelley D Miyamoto,Carmen C Sucharov

Journal of Cardiac Failure（2017）

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摘要

Unique regulation of AC and PDE isoforms supports a differential molecular adaptation to HF in children compared with adults, and may help identify mechanisms specific to the pathogenesis of pediatric HF. Greater understanding of these differences will help optimize medical therapies based on age and disease process.

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Adenylyl cyclase,phosphodiesterase,single ventricle congenital heart disease,dilated cardiomyopathy

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