Hyperintensity of the corticospinal tract on FLAIR: A simple and sensitive objective upper motor neuron degeneration marker in clinically verified amyotrophic lateral sclerosis.

•Hyperintensity of Corticospinal Tract (CST) on FLAIR MRI can be used to evaluate upper motor neuron (UMN) degeneration in ALS.•Hyperintensity of CST is a simple and sensitive objective upper motor neuron degeneration markers in ALS.•Combining CST hyperintensity and clinical examination can improve the sensitivity of diagnostic performance for UMN degeneration in ALS.