Acute myeloid leukemia with t(4;12)(q12;p13): report of 2 cases.

TO THE EDITOR: Acute myeloid leukemia (AML) with t(4;12) is rare, but its unique morphologic and clinical characteristics have been described in several reports [1,2,3,4,5,6,7,8]. Most cases show CD7 expression, low or absent myeloperoxidase activity, basophilia, unique blast morphology, dysplastic features, and poor prognosis [1,2,3,4,5,6,7,8]. Harada et al. reported that the incidence among adults is 0.6% [1,2]. ETV6, at 12p13, and CHIC2, at 4q12, have been reported to be involved in AML [5,8]. Here, we report 2 cases of AML with t(4;12) (q12;p13) which showed the common characteristics of AML with t(4;12).