In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes.

Xiange Tang,Xinyu Di,Zeyu Zhong,Qiushi Xie,Yang Chen,Fan Wang,Zhaoli Ling,Ping Xu,Kaijing Zhao,Zhongjian Wang,Li Liu,Xiaodong Liu

Journal of Pharmaceutical and Biomedical Analysis（2016）

引用 10|浏览32

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摘要

•First identification of metabolism profile of l-corydalmine (l-CDL) in vitro.•Primary enzymes and their contributions to main metabolisms formation of l-CDL.•Comparison of kinetics in human liver microsomes and recombinant P450 enzymes.

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关键词

l-Corydalmine,Metabolism,Hepatic microsomes,Cytochrome P450s,Interspecies difference

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