Amphipathic silica nanoparticles induce cytotoxicity through oxidative stress mediated and p53 dependent apoptosis pathway in human liver cell line HL-7702 and rat liver cell line BRL-3A.

Daiying Zuo,Zhenfang Duan,Yuanyuan Jia, Tianxue Chu,Qiong He,Juan Yuan,Wei Dai,Zengqiang Li,Liguo Xing,Yingliang Wu

Colloids and Surfaces B: Biointerfaces（2016）

Cited 31|Views5

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Abstract

•SiO2 NPs dose-dependently induced cytotoxicity in HL-7702 and BRL-3A cells.•SiO2 NPs induced cytotoxicity was through oxidative stress mediated and p53, caspase-3 and Bax/Bcl-2 dependent pathway.•HL-7702 cells were more sensitive to SiO2 NPs induced cytotoxicity than BRL-3A cells.•Antioxidant vitamin C significantly attenuated SiO2 NPs induced caspase-3 activation.

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Key words

Silica nanoparticles,Hepatotoxicity,Oxidative stress,p53,Apoptosis

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