Identifying Nk Alloreactive Donors For Haploidentical Hematopoietic Stem Cell Transplantation
TUMOR IMMUNOLOGY: METHODS AND PROTOCOLS(2016)
摘要
NK cell alloreactivity mediated by donor NK cells is a fundamental therapeutic tool in HLA haplotype mismatched hematopoietic transplantation in adult acute myeloid leukemia and pediatric acute lymphoblastic leukemias. NK cell is mediated by donor NK cells recovering very early after transplant. The self donor KIR ligands educates the donor NK repertoire and arms functional NK cells which express inhibitory killer cell immunoglobulin-like receptor(s) (KIRs) for self-class I ligand(s), They sense missing expression of donor KIR ligand(s) in the recipient and mediate alloreactivity. Donor-versus-recipient NK cell alloreactivity is evaluated by KIR genotyping and phenotyping and functional assay.
更多查看译文
关键词
HLA haplotype mismatched hematopoietic transplantation,NK cells,KIR genotyping,KIR phenotyping,NK cell alloreactivity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要