Central nervous system disease in childhood acute lymphoblastic leukaemia- a review.

Acute lymphoblastic leukaemia (ALL) is the commonest childhood malignancy. Despite therapeutic advancements, relapse of the pathlogical state in the form of central nervous system (CNS) disease remains a challenge. CNS disease appears to be present at diagnosis in at least 40% of patients. This relpase in the form of CNS disesase os one of the major hurdles in achieving complete cure. The present review article aims to discuss the important mechanisms of leukaemic entry and infiltration patterns of leukaemic cells into the CNS. Also, latest updates in the management stratagies of ALL will also be focused in the present article.