Multi-laboratory evaluation of SkinEthic HCE test method for testing serious eye damage/eye irritation using solid chemicals and overall performance of the test method with regard to solid and liquid chemicals testing.

N Alépée,E Adriaens,M H Grandidier,M Meloni,L Nardelli, C J Vinall,F Toner,C S Roper,A R Van Rompay,V Leblanc,J Cotovio

Toxicology in Vitro（2016）

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摘要

A prospective multicentre study of the reconstructed human corneal epithelial tissue-based in vitro test method (SkinEthic™ HCE) was conducted to evaluate its usefulness to identify chemicals as either not classified for serious eye damage/eye irritation (No Cat.) or as classified (Cat. 1/Cat. 2) within UN GHS.

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关键词

BCOP,BLR,C,CAS RN,Cat 1,Cat 2,CC,CI,CM,CO,Conj,CR,CRL,DRD,EIT,EITL,EITS,EURL ECVAM,HCE,HPLC/UPLC,ICCVAM,ICE,IR,LO,MTT,NgC,NC,No Cat,NSC,NSCkilled,NSMTT,OD,OECD,PC,PBS,pers,RhCE,RhT,SCNM,STE,S.O.P.,TG,UN GHS,VITO,VMG,VRM,WLR

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