Depletion of mitochondrial enzyme system in liver, lung, brain, stomach and kidney induced by benzo(a)pyrene.

•Significant increase in lipid peroxidation (LPO) and prominent decrease in antioxidant enzymes were induced by BaP.•Non enzymatic antioxidants and Krebs cycle’s enzymes were significantly decreased in mitochondria.•The rate of body weight increase was retarded and the disturbance of tissue homeostasis was induced by BaP.•Subchronic BaP exposure results in an organ-independent response.