Early evolving joint degeneration by cartilage trauma is primarily mechanically controlled.

K Wiegant,M Beekhuizen,S C Mastbergen,N O Kuchuk,A D Barten-van Rijbroek,R J H Custers,D B F Saris,L B Creemers,F P J G Lafeber

The Knee（2016）

Cited 2|Views8

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Abstract

•Local cartilage damage is a trigger for development of OA.•Development of OA after cartilage damage starts at the articulating opposite site.•Pro-inflammatory cytokine levels were equal in both experimental and control joints.•Early onset of the degenerative process is mechanically driven.

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Key words

Osteoarthritis,Cartilage damage,Mechanical,Inflammation,Pathogenesis

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