Two cases of cisplatin-induced permanent renal failure following neoadjuvant chemotherapy for esophageal cancer.

•Two esophageal cancer patients developed severe acute renal failure after neoadjuvant chemotherapy with cisplatin and 5-fluorourasil.•Volume expansion remains the most effective strategy for prevention of cisplatin nephrotoxicity.•The two patients described here received sufficient drip infusion and produced good urine volumes.•In both cases, renal biopsy examination indicated partial recovery of the proximal tubule, but renal function did not recover.