Clinical and Microbiological Characteristics of Invasive Group A Streptococcal Infections Before and After Implementation of a Universal Varicella Vaccine Program.

Julie Frère,Philippe Bidet,Bruce Tapiéro,Fabien Rallu,Philippe Minodier, Stephane Bonacorsi,Edouard Bingen,Philippe Ovetchkine

CLINICAL INFECTIOUS DISEASES（2016）

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摘要

Since the introduction of the varicella vaccine to the routine immunization schedule, we have observed a 70% reduction in the rate of varicella-associated invasive group A streptococcal infections (IGASI). In the mean time, the clinical presentation of IGASI and microbiological characteristics of GAS strains have changed significantly.

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invasive streptococcal infection,necrotizing fasciitis,pediatrics,varicella vaccine

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