Retrospective study evaluating the performance of a first-trimester combined screening for trisomy 21 in an Italian unselected population.

Francesco Padula,Pietro Cignini, Diana Giannarelli,Cristiana Brizzi,Claudio Coco,Laura D'Emidio,Elsa Giorgio,Maurizio Giorlandino,Lucia Mangiafico,Marialuisa Mastrandrea,Vincenzo Milite,Luisa Mobili, Cinzia Nanni, Raffaella Raffio, Cinzia Taramanni, Roberto Vigna,Alvaro Mesoraca,Domenico Bizzoco,Ivan Gabrielli,Gianluca Di Giacomo,Maria Antonietta Barone,Antonella Cima, Francesca Romana Giorlandino, Sabrina Emili, Marina Cupellaro,Claudio Giorlandino

Journal of prenatal medicine（2014）

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摘要

in our study population the detection rate for trisomy 21, using the combined risk calculation based on maternal age, fetal NT, maternal PAPP-A and free β-hCG levels, was superior to the application of either parameter alone. The algorithm has been validated for first trimester screening in the Italian population.

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关键词

Down Syndrome,SCA-Test,first trimester screening,nuchal translucency

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