Correlation Of Serum Uric Acid With Bone Mineral Density And Fragility Fracture In Patients With Primary Osteoporosis: A Single-Center Retrospective Study Of 253 Cases

Objective: This study aimed to investigate the correlation of serum uric acid with bone mineral density (BMD) and fragility fracture in primary osteoporosis (PO) patients. Methods: A retrospective analysis of biochemical parameters including bone turnover markers and bone density was done in patients (n=253) received initial treatment for PO from January 2011 to May 2012 at the Shanghai First People's Hospital. Results: Pearson correlation analysis and multiple regression analysis showed that serum uric acid positively correlated with the lumbar spine BMD (P<0.05); serum uric acid negatively correlated with urine calcium/creatinine ratio, but positively correlated with blood 25-hydroxyvitamin D (25 [OH] D) (P<0.05); the serum uric acid in postmenopausal women with the history of fragility fracture was significantly lower than that in women without the this disease history. Conclusion: Serum uric acid may be a protective factor of bone metabolism in primary osteoporosis patients.