Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

Freezing the Bioactive Conformation to Boost Potency: the Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Franz von Nussbaum,Volkhart M. -J. Li,Swen Allerheiligen,Sonja Anlauf,Lars Baerfacker,Martin Bechem,Martina Delbeck,Mary F. Fitzgerald,Michael Gerisch,Heike Gielen-Haertwig,Helmut Haning,Dagmar Karthaus,Dieter Lang,Klemens Lustig,Daniel Meibom,Joachim Mittendorf,Ulrich Rosentreter,Martina Schaefer,Stefan Schaefer,Jens Schamberger,Leila A. Telan,Adrian Tersteegen

ChemMedChem（2015）

Cited 58|Views37
Key words
biginelli reaction,biological activity,elastase inhibitors,proteases,pyrimidinones
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined