Iridium-Catalyzed Enantioselective Allyl–Allyl Cross-Coupling of Racemic Allylic Alcohols with Allylboronates
Organic Letters(2018)
Abstract
Carreira’s iridium-(P, olefin) phosphoramidite-based catalytic system that allows asymmetric allyl–allylboronate cross-coupling with high enantioselectivity is reported. This transformation tolerates a large variety of racemic branched allylic alcohols and allylboronate substrates. The utility of the coupling is demonstrated in a concise catalytic asymmetric synthesis of (−)-preclamol.
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Key words
racemic allylic alcohols,iridium-catalyzed,cross-coupling
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