A two-generation reproductive toxicity study of sodium molybdate dihydrate administered in drinking water or diet to Sprague-Dawley rats

Reproductive Toxicology(2019)

Cited 15|Views8
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Abstract
•An OECD TG-416 two-generation reproductive study of Mo as sodium molybdate dihydrate.•Rats given 0, 5, 17, or 40 mg Mo/kg/day in drinking water or 40 mg Mo/kg/day in diet.•Assessed estrus cycle, sperm, mating, fertility, litter size, pup survival & growth.•No adverse effect on reproductive function at any dose level in either generation.•NOAELs: 17 & 40 mg Mo/kg/day for systemic & reproductive toxicity respectively.
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Key words
Molybdenum,Molybdate,Reproductive toxicity,2-Generation,Rats,Drinking water,Diet,Serum
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