Early complicated schistosomiasis in a returning traveler: key contribution of new molecular diagnostic methods.

•Serology and egg microscopy lack sensitivity for early schistosomal infection.•Delayed diagnosis and treatment can lead to debilitating outcomes.•PCR assay should be performed for the early detection of symptomatic schistosomiasis.•Spinal cord schistosomiasis can appear very early after exposure.•Early ectopic granuloma formation supports prompt antischistosome drug treatment without delay.