An Enhanced Regeneration Strategy to Improve Microbial Control and Prolong RESIN Lifetime for Protein A Resin in Large-scale Monoclonal Antibody (mAb) Purification.

Journal of Biotechnology(2019)

Cited 2|Views9
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Abstract
•An enhanced Protein A resin regeneration strategy for large-scale mAb purification which.•Improves resin stability.•Provides sufficient clearance of residual products, impurities and viruses.•Improves microbial control of the process.•Extends the resin lifetime by >50%.
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Key words
MabSelect SuRe,Cleaning in Place,Sanitization in Place,Regeneration,Microbial inactivation,Resin lifetime
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