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Immunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse Trend

Samaneh Saberi,Abbas Piryaei,Esmat Mirabzadeh,Maryam Esmaeili, Toktam Karimi, Sara Momtaz,Afshin Abdirad,Niloofar Sodeifi,Mohammad Ali Mohagheghi,Hossein Baharvand,Marjan Mohammadi

Iranian biomedical journal（2019）

Cited 25|Views9
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Abstract
Our data demonstrates an inverse trend between TROY down-regulation and LGR5 up-regulation in GC tumors, as well as in response to H. pylori infection in mice. These findings support a potential negative modulatory role for TROY on LGR5 expression.
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Key words
Helicobacter pylori,Wnt signaling pathway,Stem cells,Humans,Mice
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