Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation.

•Novel salicylamide derivatives were synthesized.•Most compounds showed selective AChE inhibitory and significant antioxidant activities.•Some compounds exhibited good inhibition of self- or Cu2+-induced Aβ aggregation.•Some compounds exhibited moderate effect on the disaggregation of Aβ aggregation.•Compound 15b showed good anti-neuroinflammation activity and BBB permeability.