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转录因子FOXA1与前列腺癌恶性程度及进展相关性研究

Wei FENG,Hong-bin ZHANG,Yang-min WANG,Ju-long HU

Zhonghua nan ke xue = National journal of andrology（2015）

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Abstract
目的:探讨FOXA1与前列腺癌(PCa)临床分期、组织学分级及去势抵抗性前列腺癌(CRPC)的关系.方法:收集前列腺癌患者(35例)、良性前列腺增生(BPH)患者(21例)前列腺组织病理切片,应用免疫组化方法检测FOXA1和Ki-67的表达情况,进一步分析该分子阳性表达率与肿瘤临床分期、Gleason评分和CRPC的相关性.结果:PCa患者前列腺组织中FOXA1表达率明显高于BPH患者(100％vs 71.4％,P＜0.01),FOXA1的表达阳性率与Ki-67表达阳性率正相关(P＜0.001),与CRPC无明显相关性(P =0.391),但与Gleason评分(P=0.027)和肿瘤临床分期(P =0.002)相关. 结论:FOXA1在前列腺癌组织中表达阳性率增高,晚期前列腺癌最高.
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Key words
prostate cancer,FOXA1,tumor,gene,immunohistochemistry
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