Targeted regulation of sympathetic activity in paraventricular nucleus reduces inducible ventricular arrhythmias in rats after myocardial infarction.

Yugen Shi,Jie Yin,Hesheng Hu,Mei Xue,Xiaolu Li,Ju Liu,Yan Li,Wenjuan Cheng,Ye Wang,Xinran Li,Yu Wang,Fuhong Liu,Qiang Liu,Jiayu Tan,Suhua Yan

Journal of Cardiology（2019）

引用 9|浏览25

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摘要

•Myocardial infarction (MI) leads to an increased autonomic sympathetic excitation.•Phosphoinositide-3 kinase (PI3K)-AKT pathway in paraventricular nucleus (PVN) regulated sympathetic activity post-MI.•Inhibition of sympathetic output in PVN attenuated peripheral sympathetic activity.•Inhibition of PI3K-AKT pathway in PVN reduced ventricular arrhythmias.

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关键词

Myocardial infarction,Sympathoexcitation,Ventricular arrhythmias,Phosphoinositide-3 kinase/AKT pathway

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