Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein.
Chinese journal of integrative medicine(2019)
摘要
Curcumin can inhibit the proliferation of human colon cancer cells. Curcumin has the ability of reversal effects on the multidrug resistance of human colon cancer cells lines HCT-8/5-FU. Down-regulation of P-gp and HSP-27 may be the mechanism of curcumin reversing the drug resistance of HCT-8/5-FU to 5-FU.
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关键词
5-fluorouracil,Chinese medicine,HCT-8,HCT-8/5-FU,HSP-27,P-gp,colon cancer,curcumin,multidrug resistance
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