The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

•GPR142 functions as a selective sensor of aromatic amino acids.•GPR142 stimulates GIP, CCK and GLP-1 with GIP being particularly sensitive.•GPR142 stimulates insulin and glucagon and improves glucose tolerance.•The glucagon-mediated hepatic component of GPR142 action is significant.•Chronic GPR142 treatment increases insulin sensitivity and energy expenditure.