Activation of peripheral group III metabotropic glutamate receptors inhibits pain transmission by decreasing neuronal excitability in the CFA-inflamed knee joint.

Eui Ho Park,Seung Won Lee,Sun Wook Moon,Hye Rim Suh,Yang In Kim,Hee Chul Han

Neuroscience Letters（2019）

引用 5|浏览12

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摘要

•Peripheral group III mGluRs recover pain-like behaviors in the CFA-inflamed rats.•Peripheral group III mGluRs alleviate neuronal firing rates at the CFA-inflamed knee joint.•Inhibitory pain modulation mediated by peripheral group III mGluRs is observed only in inflammation.

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关键词

Pain transmission,CFA,Knee joint,Group III mGluR,In vivo single nerve recording,Dynamic weight bearing

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