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Analysis of Spliceosome Dynamics by Maximum Likelihood Fitting of Dwell Time Distributions.

Harpreet Kaur,Fatemehsadat Jamalidinan,Samson G F Condon,Alessandro Senes,Aaron A Hoskins

Methods（2019）

Cited 8|Views10
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Abstract
•Single-molecule methods can measure discrete binding events between individual biomolecules.•Maximum likelihood fitting of unbinned binding data can be used to determine kinetic parameters.•AGATHA software automates many time-consuming steps in data fitting and histogram analysis.
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Key words
Single-molecule,Fluorescence,Spliceosome,Dynamics,Software,Fitting
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